tomorrow's biologic solutions
Aurora BioSolutions has a focused mission to deliver real-world solutions
that protect, improve and save the lives
of the men and women who protect our freedom
and the civilian victims of war and terrorism.
Mesenchymal stromal cells (MSCs) are
multi-potent progenitor cells that promote regeneration and have anti-inflammatory and immune-modulatory benefits. We are harnessing the multi-faceted therapeutic potential of MSCs to fulfill unmet needs in combat and civilian casualty care.
In collaboration with Defence Research and Development Canada, Suffield Research Centre, we are developing a human mesenchymal stromal cell (MSC) platform to protect and treat deployed warfighters and civilians against a range of war weapons, including biological and chemical agents.
MSCs are natural immune sensors, and can generate a highly specific immune-modulatory and/or regenerative response to physical wounds and to pathogens. We are currently characterizing the responsiveness and functional potency of MSCs to a range of inflammatory stimuli.
To address current capability gaps in military medical care, we are developing MSC-based products for several combat casualty care applications. Our most advanced product is a field-deployable cell-based product designed to equip first responders, for the first time, with the capability to mitigate the sequela of untreated burn wounds.
MSCs are suitable for allogeneic transplant and are amenable to stock-piling. However, combat zones and mass casualty scenarios pose unique challenges for delivering cell therapies. We are developing new delivery methods to bring the anti-inflammatory, anti-bacterial and regenerative benefits of MSCs outside the conventional boundaries of the clinic to first responders in the field.